A holistic understanding of present and future changes within the human-water-climate nexus is crucial for sustainable and effective water management. Research at the interface of climate science and socio-hydrology is needed to address shortcomings and uncertainties in current water resources assessments and pursue developing and designing models and scenarios reflecting end-user needs. Here, we motivate and show the first steps of developing a flexible socio-hydrological modelling tool coupled with (regional) climate modelling systems to better understand and simulate interactions between human water use and the climate system.